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SCLC may be staged using the TNM system, however, it is more commonly staged using a two-stage system: Limited stage SCLC describes cancer that has yet to spread beyond one side of the chest; in many cases, this means the cancer affects one lung and potentially the lymph nodes on the same side of the body. Small cell lung cancer is divided into two stages: limited stage and extensive stage. Extensive stage. Extensive disease is TNM stage IV with distant metastases (M1) including malignant pleural effusions. Although SCLC is very chemoradiosensitive and high response rates are obtained with treatment, relapse rates are high and the prognosis remains very poor. Learn about small cell lung cancer symptoms, risk factors, diagnosis, and treatment. Please tell me if anyone has stage 4 small cell lung cancer extensive. Most patients with small-cell lung cancer (SCLC) have extensive-stage disease at presentation, and prognosis remains poor. On PubMed, the search term “extensive stage small cell lung cancer” was used and related terms were included in the search. Advanced small cell lung cancer may also be referred to as extensive-stage small cell lung cancer. In most cases, SCLC has already spread by the time it is found, so chemotherapy (chemo) is usually part of treatment.. On Medline and Cochrane, “small cell lung cancer” [MeSH term] with subheadings “drug therapy”, “radiotherapy”, “therapy” and “surgery” was used. BACKGROUND: Genomic studies in small-cell lung cancer (SCLC) lag far behind those carried out in nonsmall-cell lung cancer (NSCLC). To date, most SCLC studies have evaluated patients with surgically resectable disease. SCLC is an aggressive subtype of lung cancer and typically invades the bronchial mucosal layer (a layer of tissue in the breathing tubes). In this stage, the cancer has spread to other parts of the body such as the other lung, the bone and/or bone marrow, the brain or the fluid around the lungs. For practical reasons, small cell lung cancer (SCLC) is usually staged as either limited or extensive. N Engl J Med 2007;357:664-672.” (SCL-D) Principles of Supportive Care • … Recently, immunotherapy has demonstrated clinical activity in extensive-stage … 2016 Aug;5(4):363-6. Prophylactic cranial irradiation in extensive small-cell lung cancer. ... Extensive stage lung cancer. Comment in Transl Lung Cancer Res. Small cell lung cancer is a very aggressive form of lung cancer. Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. Small Cell Lung Cancer (SCL-C) Principles of Surgical Resection • A footnote was removed: “Slotman B, Faivre-Finn C, Kramer G, et al. Approximately 15 percent of all lung cancers are small cell lung cancers (SCLC). [3,4] (Refer to the AJCC Stage Groupings and TNM Definitions section in the PDQ summary on Non-Small Cell Lung Cancer for more information.)

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